G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24 By Raimund Mannhold, Hugo Kubinyi, Gerd Folkers(eds.)
2005 | 295 Pages | ISBN: 3527308199 | PDF | 3 MB
With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._The chaptes are all cross-referenced with each other and cover general mechnisms, methodological approaches and cover selected important GPCR sysstems, the consequences for drug action, including, side effects, and rational drug design for GPCR targets. A highly recommended reference for researchers in academia and industry. authors addresses in detail current models and concepts, so as to introduce pharmaceutical chemists, physiologists and medical researchers to the advances in the understanding of GPCR activation and constitutive activity, and provides an overview of the methods of investigating GPCR activity. The text is backed by abundant case studies and methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, and rational drug design for GPCR targets. A highly practical reference for researchers in academia and industry.Content: Chapter 1 Historical Background and Introduction (pages 1-10): Richard A. Bond and Robert J. LefkowitzChapter 2 The Nature of Constitutive Activity and Inverse Agonism (pages 11-26): Terry KenakinChapter 3 Molecular Mechanisms of GPCR Activation (pages 27-42): Soren G. F. Rasmussen and Ulrik GetherChapter 4 Molecular and Cellular Determinants of GPCR Splice Variant Constitutive Activity (pages 43-54): Joel Bockaert, Sylvie Claeysen, Lara Joubert, Laurent Fagni and Aline DumuisChapter 5 Naturally Occurring Constitutively Active Receptors: Physiological and Pharmacological Implications (pages 55-61): Alan S. Kopin and Martin BeinbornChapter 6 The Impact of G Proteins on Constitutive GPCR Activity (pages 63-70): Graeme MilliganChapter 7 (Patho)physiological and Therapeutic Relevance of Constitutive Activity and Inverse Agonism at G Protein?Coupled Receptors (pages 71-80): Lutz HeinChapter 8 Methodological Approaches (pages 81-120): Prof. Thomas Wieland and Prof. Roland SeifertChapter 9 Constitutive Activity of ??Adrenoceptors: Analysis in Membrane Systems (pages 121-140): Prof. Roland SeifertChapter 10 Constitutive Activity of ??Adrenoceptors: Analysis by Physiological Methods (pages 141-157): Ursula Ravens, Clive J. Lewis and Sian E. HardingChapter 11 Constitutive Activity at the ?1?Adrenoceptors: Past and Future Implications (pages 159-176): Susanna Cotecchia, Francesca Fanelli, Alexander Scheer and Tommaso CostaChapter 12 Constitutive Activity of Muscarinic Acetylcholine Receptors: Implications for Receptor Activation and Physiological Relevance (pages 177-193): Ethan S. Burstein and Tracy A. SpaldingChapter 13 Constitutively Active Histamine Receptors (pages 195-222): Remko A. Bakker and Rob LeursChapter 14 Constitutively Active Serotonin Receptors (pages 223-241): Katharine Herrick?DavisChapter 15 Virally Encoded Constitutively Active Chemokine Receptors (pages 243-264): Barbara Moepps and Peter Gierschik

Future Crimes: Mysteries and Detection Through Time and Space by John Brunner
English | May 19, 2021 | ISBN: N/A | ASIN: B095HZVLPS | 286 pages | EPUB | 0.76 Mb
Telepaths, time machines and alien encounters collide with the crime and mystery genre in this new collection exploring the space where detective stories and science fiction meet.

Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges By
2013 | 612 Pages | ISBN: 0470646276 | PDF | 13 MB
Fusion proteins belong to the most lucrative biotech drugs?with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins?receptor-traps, immunotoxins, Fc-fusions and peptibodies?while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals. Content: Chapter 1 Fusion Proteins: Applications and Challenges (pages 1-24): Stefan R. SchmidtChapter 2 Analyzing and Forecasting the Fusion Protein Market and Pipeline (pages 25-37): Mark Belsey and Giles SomersChapter 3 Structural Aspects of Fusion Proteins Determining the Level of Commercial Success (pages 39-56): Giles SomersChapter 4 Fusion Protein Linkers: Effects on Production, Bioactivity, and Pharmacokinetics (pages 57-73): Xiaoying Chen, Jennica Zaro and Wei?Chiang ShenChapter 5 Immunogenicity of Therapeutic Fusion Proteins: Contributory Factors and Clinical Experience (pages 75-90): Vibha Jawa, Leslie Cousens and Anne S. De GrootChapter 6 Fusion Proteins for Half?Life Extension (pages 91-106): Stefan R. SchmidtChapter 7 Monomeric Fc?Fusion Proteins (pages 107-121): Baisong Mei, Susan C. Low, Snejana Krassova, Robert T. Peters, Glenn F. Pierce and Jennifer A. DumontChapter 8 Peptide?Fc Fusion Therapeutics: Applications and Challenges (pages 123-142): Chichi Huang and Ronald V. SwansonChapter 9 Receptor?Fc and Ligand Traps as High?Affinity Biological Blockers: Development and Clinical Applications (pages 143-162): Aris N. Economides and Neil StahlChapter 10 Recombinant Albumin Fusion Proteins (pages 163-178): Thomas Weimer, Hubert J. Metzner and Stefan SchulteChapter 11 Albumin?Binding Fusion Proteins in the Development of Novel Long?Acting Therapeutics (pages 179-190): Adam Walker, Grainne Dunlevy and Peter TopleyChapter 12 Transferrin Fusion Protein Therapies: Acetylcholine Receptor?Transferrin Fusion Protein as a Model (pages 191-199): Dennis Keefe, Michael Heartlein and Serene JosiahChapter 13 Half?Life Extension through O?Glycosylation (pages 201-209): Fuad FaresChapter 14 ELP?Fusion Technology for Biopharmaceuticals (pages 211-226): Doreen M. Floss, Udo Conrad, Stefan Rose?John and Jurgen SchellerChapter 15 Ligand?Receptor Fusion Dimers (pages 227-235): Sarbendra L. Pradhananga, Ian R. Wilkinson, Eric Ferrandis, Peter J. Artymiuk, Jon R. Sayers and Richard J. RossChapter 16 Development of Latent Cytokine Fusion Proteins (pages 237-252): Lisa Mullen, Gill Adams, Rewas Fatah, David Gould, Anne Rigby, Michelle Sclanders, Apostolos Koutsokeras, Gayatri Mittal, Sandrine Vessillier and Yuti ChernajovskyChapter 17 Fusion Proteins with Toxic Activity (pages 253-269): Stefan R. SchmidtChapter 18 Classic Immunotoxins with Plant or Microbial Toxins (pages 271-293): Jung Hee Woo and Arthur FrankelChapter 19 Targeted and Untargeted Fusion Proteins: Current Approaches to Cancer Immunotherapy (pages 295-314): Leslie A. Khawli, Peisheng Hu and Alan L. EpsteinChapter 20 Development of Experimental Targeted Toxin Therapies for Malignant Glioma (pages 315-328): Nikolai G. Rainov and Volkmar HeideckeChapter 21 Immunokinases (pages 329-336): Stefan Barth, Stefan Gattenlohner and Mehmet Kemal TurChapter 22 ImmunoRNase Fusions (pages 337-353): Wojciech ArdeltChapter 23 Antibody?Directed Enzyme Prodrug Therapy (ADEPT) (pages 355-363): Surinder K. SharmaChapter 24 Tumor?Targeted Superantigens (pages 365-381): Gunnar Hedlund, Goran Forsberg, Thore Nederman, Anette Sundstedt, Leif Dahlberg, Mikael Tiensuu and Mats NilssonChapter 25 Fusion Proteins with a Targeting Function (pages 383-395): Stefan R. SchmidtChapter 26 Cell?Penetrating Peptide Fusion Proteins (pages 397-411): Andres Munoz?Alarcon, Henrik Helmfors, Kristin Karlsson and Ulo LangelChapter 27 Cell?Specific Targeting of Fusion Proteins through Heparin Binding (pages 413-427): Jiajing Wang, Zhenzhong Ma and Jeffrey A. LoebChapter 28 Bone?Targeted Alkaline Phosphatase (pages 429-439): Jose Luis MillanChapter 29 Targeting Interferon?? to the Liver: Apolipoprotein A?I as a Scaffold for Protein Delivery (pages 441-452): Jessica Fioravanti, Jesus Prieto and Pedro BerraondoChapter 30 Signal Converter Proteins (pages 453-473): Mark L. TykocinskiChapter 31 Soluble T?Cell Antigen Receptors (pages 475-493): Peter R. RhodeChapter 32 High?Affinity Monoclonal T?Cell Receptor (mTCR) Fusions (pages 495-505): Nikolai M. Lissin, Namir J. Hassan and Bent K. JakobsenChapter 33 Amediplase (pages 507-518): Stefano Evangelista and Stefano ManziniChapter 34 Breaking New Therapeutic Grounds: Fusion Proteins of Darpins and Other Nonantibody Binding Proteins (pages 519-527): Hans Kaspar BinzChapter 35 Resurgence of Bispecific Antibodies (pages 529-543): Patrick A. Baeuerle and Tobias RaumChapter 36 Novel Applications of Bispecific DART® Proteins (pages 545-555): Syd Johnson, Bhaswati Barat, Hua W. Li, Ralph F. Alderson, Paul A. Moore and Ezio BonviniChapter 37 Strand Exchange Engineered Domain (Seed): A Novel Platform Designed to Generate Mono and Multispecific Protein Therapeutics (pages 557-569): Alec W. Gross, Jessica P. Dawson, Marco Muda, Christie Kelton, Sean D. McKenna and Bjorn HockChapter 38 CovX?Bodies (pages 571-582): Abhijit Bhat, Olivier Laurent and Rodney LappeChapter 39 Modular Antibody Engineering: Antigen Binding Immunoglobulin Fc CH3 Domains as Building Blocks for Bispecific Antibodies (mAb2) (pages 583-589): Maximilian Woisetschlager, Florian Ruker, Geert C. Mudde, Gordana Wozniak?Knopp, Anton Bauer and Gottfried Himmler

Funding Ranking 2006: Institutions - Regions - Networks, DFG Approvals and Other Basic Data on Publicly Funded Research By
2007 | 179 Pages | ISBN: 3527320423 | PDF | 6 MB
Following on from previous publications in 1997, 2000 and 2003, the Deutsche Forschungsgemeinschaft (German Research Foundation) presents its fourth "Funding Ranking", an overview of the distribution of awards to universities and non-university research institutions in Germany. The scope of the report has increased considerably compared to previous editions. Alongside the report's central indicator - DFG awards per individual research institution - the document also covers a wide range of additional indicators regarding publicly financed research in one of the world's leading industrial countries. For the first time, the report also includes information on R&D funding for selected federal programmes, for thematic priorities within the European Union's Sixth Framework Programme, and for collaborative industrial research funded by the German Federation of Industrial Cooperative Research Associations "Otto von Guericke". The third party funding indicators, which each depict individual aspects of publicly financed research, represent in total approximately 80 percent of all public third party funding for university research. Content: Chapter 1 Introduction (pages 10-12): Chapter 2 Funding?Based Research Indicators - Basis and Background (pages 13-42): Chapter 3 Research Profiles of Higher Education Institutions and Regions (pages 43-62): Chapter 4 Indicator Comparison at the Level of Research and Funding Area (pages 63-113): Chapter 5 Overview (pages 114-132): Chapter 6 Bibliography and Information Sources (pages 133-134): Chapter 7 Appendix (pages 135-182):

Fundamentals of Software Testing By Bernard Homes(auth.)
2011 | 366 Pages | ISBN: 1848213247 | PDF | 13 MB
The testing market is growing at a fast pace and ISTQB certifications are being increasingly requested, with more than 180,000 persons currently certified throughout the world. The ISTQB Foundations level syllabus was updated in 2011, and this book provides detailed course study material including a glossary and sample questions to help adequately prepare for the certification exam.The fundamental aspects of testing are approached, as is testing in the lifecycles from Waterfall to Agile and iterative lifecycles. Static testing, such as reviews and static analysis, and their benefits are examined as well as techniques such as Equivalence Partitioning, Boundary Value Analysis, Decision Table Testing, State Transitions and use cases, along with selected white box testing techniques. Test management, test progress monitoring, risk analysis and incident management are covered, as are the methods for successfully introducing tools in an organization.Contents1. Fundamentals of Testing.2. Testing Throughout the Software Life Cycle.3. Static Techniques (FL 3.0).4. Test Design Techniques (FL 4.0).5. Test Management (FL 5.0).6. Tools support for Testing (FL 6.0).7. Mock Exam.8. Templates and Models.9. Answers to the Questions.Content: Chapter 1 Fundamentals of Testing (pages 1-41): Chapter 2 Testing Throughout the Software Life Cycle (pages 43-90): Chapter 3 Static Techniques (FL 3.0) (pages 91-136): Chapter 4 Test Design Techniques (FL 4.0) (pages 137-207): Chapter 5 Test Management (FL 5.0) (pages 209-276): Chapter 6 Tools support for Testing (FL 6.0) (pages 277-299): Chapter 7 Mock Exam (pages 301-314): Chapter 8 Templates and Models (pages 315-326): Chapter 9 Answers to the Questions (pages 327-329):

Fundamentals of Quality Control and Improvement: Solutions Manual to Accompany, Third Edition By Amitava Mitra(auth.)
2008 | 232 Pages | ISBN: 0470256974 | PDF | 7 MB
A statistical approach to the principles of quality control and management Incorporating modern ideas, methods, and philosophies of quality management, Fundamentals of Quality Control and Improvement, Third Edition presents a quantitative approach to management-oriented techniques and enforces the integration of statistical concepts into quality assurance methods. Utilizing a sound theoretical foundation and illustrating procedural techniques through real-world examples, this timely new edition bridges the gap between statistical quality control and quality management. The book promotes a unique "do it right the first time" approach and focuses on the use of experimental design concepts as well as the Taguchi method for creating product/process designs that successfully incorporate customer needs, improve lead time, and reduce costs. Further management-oriented topics of discussion include total quality management; quality function deployment; activity-basedcosting; balanced scorecard; benchmarking; failure mode and effects criticality analysis; quality auditing; vendor selection and certification; and the Six Sigma quality philosophy. The Third Edition also features: Presentation of acceptance sampling and reliability principles Coverage of ISO 9000 standards Profiles of past Malcolm Baldrige National Quality Award winners, which illustrate examples of best business practices Strong emphasis on process control and identification of remedial actions Integration of service sector examples The implementation of MINITAB software in applications found throughout the book as well as in the additional data sets that are available via the related Web site New and revised exercises at the end of most chapters Complete with discussion questions and a summary of key terms in each chapter, Fundamentals of Quality Control and Improvement, Third Edition is an ideal book for courses in management, technology, and engineering at the undergraduate and graduate levels. It also serves as a valuable reference for practitioners and professionals who would like to extend their knowledge of the subject.Content: Chapter 1 Introduction to Quality Control and the Total Quality System (pages 1-14): Chapter 2 Some Philosophies and their Impact on Quality (pages 15-26): Chapter 3 Quality Management: Practices, Tools, and Standards (pages 27-44): Chapter 4 Fundamentals of Statistical Concepts and Techniques in Quality Control and Improvement (pages 45-72): Chapter 5 Data Analyses and Sampling (pages 73-83): Chapter 6 Statistical Process Control using Control Charts (pages 85-95): Chapter 7 Control Charts for Variables (pages 97-123): Chapter 8 Control Charts for Attributes (pages 125-150): Chapter 9 Process Capability Analysis (pages 151-175): Chapter 10 Acceptance Sampling Plans for Attributes and Variables (pages 177-195): Chapter 11 Reliability (pages 197-202): Chapter 12 Experimental Design and the Taguchi Method (pages 203-232):

Fundamentals of Electrochemistry, Second Edition By V. S. Bagotsky(auth.)
2005 | 720 Pages | ISBN: 0471700584 | PDF | 6 MB
Fundamentals of Electrochemistry provides the basic outline of most topics of theoretical and applied electrochemistry for students not yet familiar with this field, as well as an outline of recent and advanced developments in electrochemistry for people who are already dealing with electrochemical problems. The content of this edition is arranged so that all basic information is contained in the first part of the book, which is now rewritten and simplified in order to make it more accessible and used as a textbook for undergraduate students. More advanced topics, of interest for postgraduate levels, come in the subsequent parts. This updated second edition focuses on experimental techniques, including a comprehensive chapter on physical methods for the investigation of electrode surfaces. New chapters deal with recent trends in electrochemistry, including nano- and micro-electrochemistry, solid-state electrochemistry, and electrocatalysis. In addition, the authors take into account the worldwide renewal of interest for the problem of fuel cells and include chapters on batteries, fuel cells, and double layer capacitors.Content: Chapter 1 Electric Currents in Ionic Conductors (pages 1-18): Chapter 2 Electrode Potentials (pages 19-31): Chapter 3 Thermodynamics of Electrochemical Systems (pages 33-50): Chapter 4 Mass Transfer in Electrolytes (pages 51-67): Chapter 5 Phase Boundaries (Interfaces) between Miscible Electrolytes (pages 69-77): Chapter 6 Polarization of Electrodes (pages 79-98): Chapter 7 Aqueous Electrolyte Solutions (pages 99-126): Chapter 8 Nonaqueous Electrolytes (pages 127-137): Chapter 9 Electron Work Functions and Volta Potentials (pages 139-146): Chapter 10 Structure and Properties of Surface Layers (pages 147-180): Chapter 11 Transient Processes (pages 181-189): Chapter 12 Electrochemical Research Techniques (pages 191-215): Chapter 13 Multistep Electrode Reactions (pages 217-237): Chapter 14 Some Aspects of Electrochemical Kinetics (pages 239-260): Chapter 15 Reactions at Nonconsumable Electrodes (pages 261-295): Chapter 16 Reactions Involving Metals (pages 297-317): Chapter 17 Industrial Electrolytic Processes (pages 319-325): Chapter 18 Electrochemical Reactors (pages 327-342): Chapter 19 Batteries (Electrochemical Power Sources) (pages 343-360): Chapter 20 Fuel Cells (pages 361-368): Chapter 21 Some Electrochemical Devices (pages 369-377): Chapter 22 Corrosion of Metals (pages 379-386): Chapter 23 Electrochemical Methods of Analysis (pages 387-403): Chapter 24 Electrochemistry and the Environment (pages 405-416): Chapter 25 Solid?State Electrochemistry (pages 417-447): Chapter 26 Conductive Polymers (pages 449-465): Chapter 27 Physical Methods for Investigation of Electrode Surfaces (pages 467-519): Chapter 28 Electrocatalysis (pages 521-555): Chapter 29 Photoelectrochemistry (pages 557-571): Chapter 30 Bioelectrochemistry (pages 573-593): Chapter 31 Electrokinetic Processes (pages 595-606): Chapter 32 Interfaces Between Two Immiscible Electrolyte Solutions (pages 607-619): Chapter 33 Various Electrochemical Phenomena (pages 621-635): Chapter 34 Main Concepts of Elementary Reaction Act Theory (pages 637-660): Chapter 35 Computer Simulation in Electrochemistry (pages 661-677): Chapter 36 Nanoelectrochemistry (pages 679-691): Chapter 37 Development of Electrochemistry (pages 693-700):

Functional Genomics in Aquaculture By
2012 | 423 Pages | ISBN: 0470960086 | PDF | 6 MB
Genomics has revolutionized biological research over the course of the last two decades. Genome maps of key agricultural species have offered increased understanding of the structure, organization, and evolution of animal genomes. Building upon this foundation, researchers are now emphasizing research on genome function. Published with the World AquacultureSociety,Functional Genomics in Aquaculture looks at the advances in this field as they directly relate to key traits and species in aquaculture production.Functional Genomics in Aquaculture opens with two chapters that provide a useful general introduction to the field of functional genomics. The second section of the book focuses on key production traits such as growth, development, reproduction, nutrition, and physiological response to stress and diseases. The final five chapters focus on a variety of key aquaculture species. Examples looking at our understanding of the functional genomes of salmonids, Mediterranean sea bass, Atlantic cod, catfish, shrimp, and molluscs, are included in the book.Providing valuable insights and discoveries into the functional genomes of finfish and shellfish species, Functional Genomics in Aquaculture, will be an invaluable resource to researchers and professionals in aquaculture, genetics, and animal science.Content: Chapter 1 Functional Genomics Research in Aquaculture: Principles and General Approaches (pages 1-40): Shikai Liu, Yu Zhang, Fanyue Sun, Yanliang Jiang, Ruijia Wang, Chao Li, Jiaren Zhang and Zhanjiang (john) LiuChapter 2 Genomic Resources for Functional Genomics in Aquaculture Species (pages 41-77): Jiaren Zhang, Yanliang Jiang, Fanyue Sun, Yu Zhang, Ruijia Wang, Chao Li, Shikai Liu and Zhanjiang (john) LiuChapter 3 Production, Growth, and Insulin?Like Growth Factor?I (IGF?I) Gene Expression as an Instantaneous Growth Indicator in Nile Tilapia Oreochromis Niloticus (pages 79-89): Christopher L. Brown, Emmanuel M. vera Cruz, Remedios B. Bolivar and Russell J. BorskiChapter 4 Gene Expression Pattern during European Sea Bass Larvae Development: Impact of Dietary Vitamins (pages 91-111): David Mazurais, Maria Darias, Ignacio Fernandez, Chantal Cahu, Enric Gisbert and Jose?Luis Zambonino?InfanteChapter 5 Transcriptomics of the Compensatory Growth in European Sea Bass Dicentrarchus labrax (pages 113-128): Genciana Terova, Samuela Cora, Tiziano Verri, Rosalba Gornati, Giovanni Bernardini and Marco SarogliaChapter 6 Functional Genomic Analysis of the Nutritional and Hormonal Regulation of Fish Glucose and Lipid Metabolism (pages 129-145): Sandrine Skiba?Cassy, Sergio Polakof, Iban Seilez and Stephane PanseratChapter 7 Genomic Responses to Stress Challenges in Fish (pages 147-168): Lluis Tort and Mariana TelesChapter 8 Functional Genomic Analysis of Sex Determination and Differentiation in Teleost Fish (pages 169-204): Francesc Piferrer, Paulino Martenez, Laia Ribas, Ana Vi?nas and Noelia DiazChapter 9 Functional Genomics of Stress: Molecular Biomarkers for Evaluating Fish CNS Activity (pages 205-218): Chiara Tognoli, Rosalba Gornati, Marco Saroglia, Genciana Terova and Giovanni BernardiniChapter 10 The SoLute Carrier (SLC) Family Series in Teleost Fish (pages 219-320): Tiziano Verri, Genciana Terova, Alessandro Romano, Amilcare Barca, Paola Pisani, Carlo Storelli and Marco SarogliaChapter 11 Next?Generation Sequencing and Functional Genomic Analysis in Rainbow Trout (pages 321-337): Mohamed SalemChapter 12 Functional Genomics Research of Atlantic Cod Gadus morhua (pages 339-348): Matthew L. RiseChapter 13 Catfish Functional Genomics: Progress and Perspectives (pages 349-360): Eric PeatmanChapter 14 Functional Genomics in Shrimp Disease Control (pages 361-375): Arun K. Dhar and Refugio Robles?SikisakaChapter 15 Applications of Functional Genomics in Molluscs Aquaculture (pages 377-395): A. Figueras, M. M. Costa and B. Novoa

Full-Field Measurements and Identification in Solid Mechanics By
2012 | 485 Pages | ISBN: 1848212941 | PDF | 14 MB
This timely book presents cutting-edge developments by experts in the field on the rapidly developing and scientifically challenging area of full-field measurement techniques used in solid mechanics - including photoelasticity, grid methods, deflectometry, holography, speckle interferometry and digital image correlation. The evaluation of strains and the use of the measurements in subsequent parameter identification techniques to determine material properties are also presented.Since parametric identification techniques require a close coupling of theoretical models and experimental measurements, the book focuses on specific modeling approaches that include finite element model updating, the equilibrium gap method, constitutive equation gap method, virtual field method and reciprocity gap method. In the latter part of the book, the authors discuss two particular applications of selected methods that are of special interest to many investigators: the analysis of localized phenomenon and connections between microstructure and constitutive laws. The final chapter highlights infrared measurements and their use in the mechanics of materials.Written and edited by knowledgeable scientists, experts in their fields, this book will be a valuable resource for all students, faculties and scientists seeking to expand their understanding of an important, growing research areaContent: Chapter 1 Basics of Metrology and Introduction to Techniques (pages 1-30): Andre Chrysochoos and Yves SurrelChapter 2 Photoelasticity (pages 31-60): Fabrice Bremand and Jean?Christophe DupreChapter 3 Grid Method, Moire and Deflectometry (pages 61-92): Jerome Molimard and Yves SurrelChapter 4 Digital Holography Methods (pages 93-124): Pascal Picart and Paul SmigielskiChapter 5 Elementary Speckle Interferometry (pages 125-156): Pierre Jacquot, Pierre Slangen and Dan BorzaChapter 6 Digital Image Correlation (pages 157-190): Michel Bornert, Francois Hild, Jean?Jose Orteu and Stephane RouxChapter 7 From Displacement to Strain (pages 191-222): Pierre FeisselChapter 8 Introduction to Identification Methods (pages 223-246): Marc BonnetChapter 9 Parameter Identification from Mechanical Field Measurements using Finite Element Model Updating Strategies (pages 247-274): Emmanuel Pagnacco, Anne?Sophie Caro?Bretelle and Patrick IennyChapter 10 Constitutive Equation Gap (pages 275-300): Stephane Pagano and Marc BonnetChapter 11 Virtual Fields Method, The (pages 301-330): Michel Grediac, Fabrice Pierron, Stephane Avril, Evelyne Toussaint and Marco RossiChapter 12 Equilibrium Gap Method (pages 331-362): Fabien Amiot, Jean?Noel Perie and Stephane RouxChapter 13 Reciprocity Gap Method (pages 363-378): Stephane Andrieux, Huy Duong Bui and Andrei ConstantinescuChapter 14 Characterization of Localized Phenomena (pages 379-410): Jacques Desrues and Julien RethoreChapter 15 From Microstructure to Constitutive Laws (pages 411-438): Jerome Crepin and Stephane RouxChapter 16 Thermographic Analysis of Material Behavior (pages 439-468): Jean?Christophe Batsale, Andre Chrysochoos, Herve Pron and Bertrand Wattrisse

Frontiers in Geochemistry: Contribution of Geochemistry to the Study of the Earth By
2011 | 278 Pages | ISBN: 1405193387 | PDF | 14 MB
This book is a contribution to the International Year of Planet Earth arising from the 33rd International Geological Congress, held in Oslo, Norway during August 2008. The first section of the book considers aspects of geochemical processes which led to the development of the solid Earth as it is today. The second portion of the book shows how the rapidly-evolving analytical tools and approaches presently used by geochemists may be used to solve emerging environmental and other societal problems. Thisunique collection of reviews, with contributions from a range of internationally distinguished scientists, will be invaluable reading for advanced students and others interested in the central role geochemistry in the earth sciences.Content: Chapter 1 Geochemistry and Secular Geochemical Evolution of the Earth's Mantle and Lower Crust (pages 1-19): Balz S. KamberChapter 2 Crustal Evolution - A Mineral Archive Perspective (pages 20-42): C. J. Hawkesworth, A. I. S. Kemp, B. Dhuime and C. D. StoreyChapter 3 Discovering the History of Atmospheric Oxygen (pages 43-60): Heinrich D. HollandChapter 4 Geochemistry of the Oceanic Crust (pages 61-83): Karsten M. HaaseChapter 5 Silicate Rock Weathering and the Global Carbon Cycle (pages 84-103): Sigurdur R. Gislason and Eric H. OelkersChapter 6 Geochemistry of Secular Evolution of Groundwater (pages 104-116): Tomas PacesChapter 7 Stable Isotope Geochemistry: Some Perspectives (pages 117-131): Jochen HoefsChapter 8 Geochemistry of Geologic Sequestration of Carbon Dioxide (pages 133-174): Yousif K. Kharaka and David R. ColeChapter 9 Microbial Geochemistry: At the Intersection of Disciplines (pages 175-199): Philip Bennett and Christopher OmelonChapter 10 Nanogeochemistry: Nanostructures and their Reactivity in Natural Systems (pages 200-220): Yifeng Wang, Huizhen Gao and Huifang XuChapter 11 Urban Geochemistry (pages 221-237): Morten Jartun and Rolf Tore OttesenChapter 12 Archaeological and Anthropological Applications of Isotopic and Elemental Geochemistry (pages 238-253): Henry P. Schwarcz